陈显军 教授
生物工程专业：博士生导师/工程博士导师
药学专业：硕士生导师/工程硕士导师
生物与医药工程专业：工程博士导师
生物反应器工程国家重点实验室PI
光遗传学与合成生物学交叉学科研究中心核心成员
上海市细胞代谢光遗传学技术前沿科学研究基地成员
联系方式
电话/传真：021-64251287
E-mail: xianjunchen@ecust.edu.cn
通讯地址：上海市徐汇区梅陇路130号5845威尼斯.com光遗传学与合成生物学交叉学科研究中心315室，邮编：200237
个人简介
2009年本科毕业于5845威尼斯.com生物工程学院生物技术专业。2015年博士毕业于5845威尼斯.com化学生物技术与工程专业。2016年1月开始博士后研究，先后任5845威尼斯.com特聘副研究员、教授。迄今已在Nature Biotechnology (2019, Cover story; 2022), Nature Methods、Nature Chemical Biology、Nature Communications（2021; 2023)、Nature Protocols, Cell Research、Cell Discovery、Nucleic Acids Research (2016; 2020)、Biosensors and Bioelectronics、Journal of Controlled Release等期刊发表SCI论文多篇，编写英文著作Curr Protoc Chem Biol 1个章节。已申请多项中国发明专利（授权2项）和国际PCT专利（分别授权2项美国、日本和欧洲发明专利）。主持国家重点研发计划课题/子课题、国家自然科学基金原创/面上/青年基金、上海市自然科学基金等多项国家与省部级基金项目，先后入选国家级高层次青年人才、中国科协青年人才托举工程、上海市青年科技启明星，获得上海市生物化学与分子生物学学会第二届“青年新锐奖”、5845威尼斯.com青年五四奖章、“东岳药业”研究生奖教金特等奖。
研究方向
1、新型光遗传学技术的开发与应用
2、生物大分子荧光标记技术开发与应用
研究生招生
团队（杨弋教授领衔的光遗传学与合成生物学交叉学科研究中心）研究对象涉及基因、蛋白质、细菌、哺乳动物细胞、线虫、斑马鱼、果蝇和小鼠，研究领域涉及细胞生物学、生物化学与分子生物学、合成生物学、光遗传学、化学遗传学、化学生物学等。本团队热忱欢迎有志于从事光遗传学、合成生物学、化学生物学研究的同学加盟本团队。
代表性论文（#第一作者，*通讯作者）
(1) Renmei Liu#, Jing Yao#, Siyu Zhou#, Jing Yang#, Yaqiang Zhang, Xiaoyan Yang, Leshi Li, Yunbin Zhang, Yingping Zhuang, Yi Yang*, Xianjun Chen*,Spatiotemporal control of RNA metabolism and CRISPR-Cas functions using engineered photoswitchable RNA-binding proteins, Nature Protocols, 2023, accepted.
(2) Li Jiang#, Xin Xie#, Ni Su#, Dasheng Zhang#, Xianjun Chen# *, Xiaochen Xu#, Bibi Zhang, Kaiyi Huang, Jingwei Yu, Mengyue Fang, Bingkun Bao, Fangting Zuo, Lipeng Yang, Rui Zhang, Huiwen Li, Xinyi Huang, Zhengda Chen, Qingmei Zeng, Renmei Liu, Qiuning Lin, Yuzheng Zhao, Aiming Ren*, Linyong Zhu*, Yi Yang*,Large Stokes shift fluorescent RNAs for dual-emission fluorescence and bioluminescence imaging in live cells, Nature Methods, 2023, 10.1038/s41592-023-01997-7.
(3) Yi Cheng, Jiafeng Zou, Muye He, Xinyu Hou, Hongtao Wang, Jiajun Xu, Zeting Yuan, Minbo Lan, Yi Yang, Xianjun Chen*, Feng Gao*,Spatiotemporally controlled Pseudomonas exotoxin transgene system combined with multifunctional nanoparticles for breast cancer antimetastatic therapy, Journal of Controlled Release, 2023, S0168-3659(23)00507-2.
(4) Dasheng Zhang#, Zhengda Chen#, Zengmin Du#, Bingkun Bao#, Ni Su#, Xianjun Chen*, Yihui Ge, Qiuning Lin, Lipeng Yang, Yujie Hua, Shuo Wang, Xin Hua, Fangting Zuo, Ningfeng Li, Renmei Liu, Li Jiang, Chunyan Bao, Yuzheng Zhao, Joseph Loscalzo, Yi Yang* and Linyong Zhu*, Design of a palette of SNAP-tag mimics of fluorescent proteins and their use as cell reporter, Cell Discovery,2023, 9, 56.
(5) Mengyue Fang#, Huiwen Li#, Xin Xie#, Hui Wang, Ying Jiang, Tianyu Li, Bibi Zhang, Xin Jiang, Yueyang Cao, Rui Zhang, Dasheng Zhang, Yuzheng Zhao, Linyong Zhu, Xianjun Chen*, Yi Yang*. Imaging intracellular metabolite and protein changes in live mammalian cells with bright fluorescent RNA-based genetically encoded sensors, Biosensors and Bioelectronics, 2023, 235, 115411.
(6) Miaowei Mao#, Yajie Qian#, Wenyao Zhang#, Siyu Zhou, Zefeng Wang, Xianjun Chen*, Yi Yang*. Controlling protein stability with SULI, a highly sensitive tag for stabilization upon light induction, Nature Communications,2023, 14, 2172.
(7) Yajie Qian#, Ting Li#, Siyu Zhou, Xianjun Chen*, Yi Yang*, A Single-Component Optogenetic Gal4-UAS System Allows Stringent Control of Gene Expression in Zebrafish and Drosophila, ACS Synthetic Biology, 2023, 12, 664-671.
(8) Muye He, Yuji Sun, Yi Cheng, Jie Wang, Miao Zhang, Rui Sun, Xinyu Hou, Jiajun Xu, Hai He , Hongtao Wang, Zeting Yuan, Minbo Lan, Yuzheng Zhao, Yi Yang, Xianjun Chen*, Feng Gao*, Spatiotemporally controllable diphtherin transgene system and neoantigen immunotherapy, Journal of Controlled Release, 2023, 355, 538–551.
(9) Renmei Liu#, Jing Yang#, Jing Yao, Zhou Zhao, Dr Wei He, Ni Su, Zeyi Zhang, Chenxia Zhang, Zhuo Zhang, Haibo Cai, Linyong Zhu, Yuzheng Zhao, Shu Quan, Xianjun Chen*, Yi Yang*, Optogenetic control of RNA function and metabolism using engineered light-switchable RNA-binding proteins, Nature Biotechnology, 2022, 40, 779-786.
(10) Kaiyi Huang#, Xianjun Chen#, Chunyan Li, Qianqian Song, Huiwen Li, Linyong Zhu*, Yi Yang*, Aiming Ren*, Structure-based investigation of fluorogenic Pepper aptamer, Nature Chemical Biology, 2021, 17, 1289-1295.
(11) Ting Li#, Xianjun Chen#, Yajie Qian, Jiawei Shao, Xie Li, Shuning Liu, Linyong Zhu, Yuzheng Zhao, Haifeng Ye* & Yi Yang*, A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice. Nature Communications, 2021, 12, 615.
(12) Xinyu Hou, Chenting Shou, Muye He, Jiajun Xu, Yi Cheng, Zeting Yuan, Minbo Lan, Yuzheng Zhao, Yi Yang, Xianjun Chen*, Feng Gao*, A combination of LightOn gene expression system and tumor microenvironment-responsive nanoparticle delivery system for targeted breast cancer therapy. Acta Pharmaceutica Sinica B, 2020, 10, 1741-1753.
(13) Xie Li, Changcheng Zhang, Xiaopei Xu, Jun Miao, Jing Yao, Renmei Liu, Yuzheng Zhao, Xianjun Chen*, Yi Yang*. A single-component light sensor system allows highly tunable and direct activation of gene expression in bacterial cells. Nucleic Acids Research, 2020, 48, e33.
(14) Jiajun Xu, Muye He, Xinyu Hou,Yan Wang,Chenting Shou, Xiaoran Cai, Zeting Yuan, Yu Yin, Minbo Lan, Kaiyan Lou, Yuzheng Zhao, Yi Yang, Xianjun Chen*, Feng Gao*, Safe and Efficacious Diphtheria Toxin-Based Treatment for Melanoma: Combination of a Light-On Gene-Expression System and Nanotechnology. Molecular pharmaceutics, 2020, 17 (1), 301-315.
(15) Xianjun Chen#, Dasheng Zhang#, Ni Su#, Bingkun Bao, Xin Xie, Fangting Zuo, Lipeng Yang, Hui Wang, Li Jiang, Qiuning Lin, Mengyue Fang, Ningfeng Li, Xin Hua, Zhengda Chen, Chunyan Bao, Jinjin Xu, Wenli Du, Lixin Zhang, Yuzheng Zhao, Linyong Zhu*, Joseph Loscalzo, Yi Yang*, Visualizing RNA Dynamics in Live Cells with Bright and Stable Fluorescent RNAs, Nature Biotechnology, 2019, 37: 1287-1293.
(16) Xiaopei Xu, Zhaoxia Du, Renmei Liu, Ting Li, Yuzheng Zhao, Xianjun Chen* and Yi Yang*, A Single-Component Optogenetic System Allows Stringent Switch of Gene Expression in Yeast Cells, ACS Synthetic Biology, 2018, 7: 2045-2053.
(17) Wansheng Sun, Wenyao Zhang, Chao Zhang, Miuwei Mao, Yuzheng Zhao, Xianjun Chen*, and Yi Yang*, Light-induced protein degradation in human-derived cells. Biochemical and Biophysical Research Communications, 2017, 487, 241-246.
(18) Xianjun Chen, Renmei Liu, Zhengcai Ma, Xiaopei Xu., Haoqian Zhang, Jianhe Xu, Qi Ouyang, and Yi Yang*, An extraordinary stringent and sensitive light-switchable gene expression system for bacterial cells, Cell Research, 2016, 26: 854-857.
(19) Xianjun Chen#, Ting Li#, Xue Wang, Zengmin Du, Renmei Liu, and Yi Yang*, Synthetic dual-input mammalian genetic circuits enable tunable and stringent transcription control by chemical and light, Nucleic Acids Research, 2016, 44: 2677-2690.
(20) Xianjun Chen, Ting Li, Xue Wang, and Yi Yang*, A light-switchable bidirectional expression module allowing simultaneous regulation of multiple genes, Biochemical and Biophysical Research Communications, 2015, 465: 769-776.
(21) Xue Wang, Xianjun Chen, and Yi Yang*, Spatiotemporal control of gene expression by a light-switchable transgene system, Nature Methods, 2012, 9: 266-269.