李婷     博士/特聘副研究员/硕导

       电话/传真：021-64251287

              E-mail:  tingli@ecust.edu.cn

      通讯地址：上海市徐汇区梅陇路130号实验十八楼733；邮编：200237

个人简介

2018年9月毕业于5845威尼斯.com，获生物化学与分子生物学专业的博士学位，随后进入5845威尼斯.com药学专业从事博士后研究工作。2022年7月出站留校工作，被聘为特聘副研究员，在赵玉政教授团队从事教学科研工作。

聚焦细胞代谢监控技术开发与生物医药研究，通过细胞药物治疗、高通量代谢药物筛选、在体可视化追踪、药物靶点研究及临床疾病危险标志物发现等方式揭示生命过程的化学本质，解析疾病发生发展机制，促进生物医药的发展。主要研究成果发表在Cell Metabolism、Nature Communications、Nucleic Acids Research、Cell Regeneration、Developmental Cell、Nature Protocols等国内外知名学术期刊,申请发明专利4项。入选2019年上海市青年科技英才扬帆计划，同年获得国家自然科学基金青年科学基金项目和中国博士后科学基金面上项目。

研究方向

1. 基于光遗传学的细胞控制技术的开发与应用

2. 细胞代谢监测成像新技术的开发与应用

   
   

代表性论文

1. Xie Li^#, Yinan Zhang^#, Lingyan Xu^#, Aoxue Wang^#, Yejun Zou^#, Ting Li^#, Li Huang^#, Weicai Chen^#, Shuning Liu, Kun Jiang, Xiuze Zhang, Dongmei Wang, Lijuan Zhang, Zhuo Zhang, Zeyi Zhang, Xianjun Chen, Wei Jia, Aihua Zhao, Xinfeng Yan, Linyong Zhu, Xinran Ma, Zhenyu Ju, Weiping Jia, Congrong Wang*, Joseph Loscalzo, Yi Yang*, Yuzheng Zhao*.Ultrasensitive sensors reveal the spatiotemporal landscape of lactate metabolism in physiology and disease. Cell Metabolism, 2023, 35(1), 200-211.

2. Yajie Qian^#, Ting Li^#, Siyu Zhou, Xianjun Chen* and Yi Yang*,  A single-component optogenetic Gal4-UAS system allows stringent control of gene expression in zebrafish and Drosophila. ACS Synthetic Biology, 2023, 12(3), 664-671.

3. Ting Li^#, Yejun Zou^#, Shuning Liu,Yi Yang, Zhuo Zhang*, Yuzheng Zhao*. Monitoring NAD(H) and NADP(H) dynamics during organismal development with genetically encoded fluorescent biosensors.Cell Regeneration, 2022, 11(1): 5.

4. Ting Li^#, Xianjun Chen^#, Yajie Qian, Jiawei Shao, Xie Li, Shuning Liu, Linyong Zhu, Yuzheng Zhao, Haifeng Ye* and Yi Yang*. A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice. Nature Communications, 2021, 12(1): 615.

5. Xianjun Chen^#, Ting Li^#, Xue Wang, Zengmin Du, Renmei Liu, and Yi Yang*, Synthetic dual-input mammalian genetic circuits enable tunable and stringent transcription control by chemical and light, Nucleic Acids Research, 2016, 44(6): 2677-2690.

6. Xiaopei Xu, Zhaoxia Du, Renmei Liu, Ting Li, Yuzheng Zhao, Xianjun Chen* and Yi Yang*, A single-component optogenetic system allows stringent switch of gene expression in yeast cells, ACS Synthetic Biology, 2018, 7(9): 2045-2053.

7. Yejun Zou^#, Aoxue Wang^#, Mei Shi, Xianjun Chen, Renmei Liu,Ting Li, Chenxia Zhang, Zhuo Zhang, Linyong Zhu, Zhenyu Ju, Joseph Loscalzo, Yi Yang*, Yuzheng Zhao*, Analysis of redox landscapes and dynamics in living cells and in vivo using genetically encoded fluorescent sensors, Nature Protocols, 2018, 13(10): 2362-2386.

8. Yejun Zou^#, Aoxue Wang^#, Li Huang^#, Xudong Zhu^#, Qingxun Hu^#, Yinan Zhang, Xianjun Chen, Fengwen Li, Qiaohui Wang, Hu Wang, Renmei Liu, Fangting Zuo, Ting Li, Jing Yao, Yajie Qian,Mei Shi, Xiao Yue, Weicai Chen, Zhuo Zhang, Congrong Wang, Yong Zhou, Linyong Zhu, Zhenyu Ju, Joseph Loscalzo, Yi Yang*, Yuzheng Zhao*. Illuminating NAD+ metabolism in live cells and in vivo using a genetically encoded fluorescent sensor. Developmental Cell, 2020, 53(2): 240-252.

9. Xianjun Chen;Ting Li; Xue Wang; Yi Yang*; A light-switchable bidirectional expression module allowing simultaneous regulation of multiple genes, Biochemical and Biophysical Research Communications, 2015, 465(4): 769-776.